Review: once daily LMWH is as effective as twice daily LMWH for initial treatment of venous thromboembolism

摘要

5 RCTs (n= 1508) met the selection criteria, 1 of the RCTs enrolled patients with DVI and PE, and the rest included only patients with DVT. Brands of LMWH included dalteparin, enoxapaiin, nadroparin, and tinzaparin In all RCTs, the same generic compounds were used in head to head comparisons of once and twice daily treatment regimens Meta-analysis was done using a fixed effects model Once daily and twice daily treatment regimens did not differ for any of the outcomes (table).