Use of oral contraceptives is not associated with increased risk of death in the UK; a net benefit in all-cause mortality was seen in ever users versus never users - RR 0.88, 95% CI 0.82 to 0.93.

摘要

The combined oral contraceptive pill (OCP) was first used in 1956 in Puerto Rico and is frequently referred to as 'the Pill'. It is a combination of oral oestrogen and a pro-gestin {progestogen) taken for contraception by over 100 million women worldwide. The OCPs were perceived as a convenient, effective and reversible means of contraception. Ever since OCPs were first introduced, their relative safety has been the focus of much debate.1 Concerns are derived from the influences that these hormone-based therapies are used upon a series of adverse events including circulatory disease and cancer.2 Since the introduction of OCPs in the 1960s, sufficient time has now elapsed to allow investigators to complete an adequately powered cohort study to determine the RRs associated with the use of OCPs. The Royal College of General Practitioners' Oral Contraception Study is one of the largest studies considering the relative safety of OCPs.