Descending necrotizing mediastinitis (DNM) is a rare, highly fatal disease that occurs as a complication of a cervical or odontogenic infection spreading into the mediastinum. We herein report of a 50-year-old man with DNM and severe thoracic emphysema who was successfully treated using surgical drainage by video-assisted thoracoscopic surgery (VATS) and a transcervical approach. Chest enhanced computed tomography on admission revealed massive left pleural effusion, pneumothorax, absolute collapse of the left lung, and a mediastinal shift to the right side with emphysema. We urgently performed left thoracic and mediastinal drainage using VATS. Retropharyngeal and upper mediastinal drainage was performed transcervically on the third hospital day. He recovered and was discharged on hospital day 57. Surgical drainage is the most important therapy in the treatment of DNM, but there is no standard surgical approach. We believe that VATS is a less invasive, effective modality for draining the posterior mediastinum.
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