Tandem aldol condensation/platinacycle-catalyzed addition reactions of aldehydes, methyl ketones, and arylboronic acids

摘要

Aldol condensation of aldehydes with methyl ketones followed by anionic four-electron donor-based(type I) platinacycle-catalyzed addition reactions of arylboronic acids to form β-arylated ketones is described. Good to excellent yields of β-arylated ketones were obtained for the tandem reactions of aromatic/aliphatic aldehydes, methyl ketones, and arylboronic acids, and moderate yields were observed for the tandem reactions of α,β-unsaturated aldehydes. The aldol condensation of aldehydes with methyl ketones was successfully combined with the platinacycle-catalyzed addition reactions of arylboronic acids in a tandem fashion. A variety of β-arylated ketones was obtained in good to excellent yields.