Formation of alpha-Amino ketones:addition of acylzirconocene chlorides to imines catlayzed by Yb(OTf)_3/TmsOTf and bronsted acids and three-component reactions of acylzirconocene chlorides,aldehydes,and amines

摘要

A direct preparation of alpha-amino ketone derivatives through treatment of acylzirconocene chlorides with N-benzylidene-aniline derivatives,in which acylzirconocene chlorides react as "unmasked" acyl anion donors,was carried out under Yb(OTf)_3/TMSOTf-catlayzed conditions.The same reactions were also carried out with the sue of Bronsted acids as catalyst in place of Yb(OTf)_3/TMSOTf.The operatinally simple three-component reaction with aldehydes,anilines,and acylzirconocene chlorides affords alpha-amino ketone derivatives essentially in the absence of a catlayst.