Effects of Extended Aryl-Substituted Bisoxazoline Ligands in Asymmetric Synthesis - Efficient Synthesis and Application of 4,4'-Bis(l-Naphthyl)-,4,4'-Bis(2-Naphthyl)-and 4,4'-Bis(9-Anthryl)-2,2'-isopropylidenebis(l,3-oxazolines)

摘要

The steric influence of extended aryl substituents on 2,2'-bis(l,3-oxazoline) ligands was investigated in a series of asymmetric catalytic reactions such as Mukaiyama aldol and Michael reactions,hetero-Diels-Alder processes,and allylic alkylation reactions.4,4'-(2-Naphthyl)- and 4,4'-(9-anthryl)-substituted isopropylidene-bridged 2,2'-bis(l,3-oxazolines) were synthesized and their enantioselective and catalytic properties in combination with different metals evaluated.