Heterogeneous bisoxazoline/copper complex: A green catalyst for the enantioselective reaction of nitromethane with substituted benzaldehydes

摘要

Polystyrene-supported chiral 2,2′-methylenebis[(4S)-4-tert-butyl-2- oxazoline] is a promising heterogeneous catalyst for the enantioselective Henry reaction of nitromethane with substituted benzaldehydes. The process is carried out in ethanol as a green solvent, and the corresponding chiral β-nitroalcohols are obtained in 56-95 % yield with 49-88 % ee.