Comment on papper: Cyclooxygenase-2 expression in primary and recurrent pterygium.

摘要

We read with interest the recent article on cyclooxygenase-2 (COX-2) expression in pterygium by Adiguzel et al (1). Although we agree with the authors on general comments, some points should be clarified in this study.The authors reported a different primary pterygium staining result from our previous study (2). They attributed the inconsistency to the different scoring systems of staining. In addition, the following factors should also be considered: different demographics in terms of race or gender; different pterygium characteristics in severity (atrophic, intermediate, and fleshy) and area (leading edges, head, or body); and different immuno-histochemistry methodology in antibodies and cutoff level. Those factor scan result in different results. We discussed the same issue in our previous report in p53 expression in pterygium (3).