Description of a new, endoscopic technique to remove the over-the-scope-clip in an ex vivo porcine model (with video)

摘要

Background: Various studies have demonstrated the usefulness of the over-the-scope-clip (OTSC) to treat perforations, anastomotic leaks, and fistulae. Endoscopic removal of the OTSC was previously described in a series of 3 patients by using the Nd:YAG laser.Objective: To evaluate a new endoscopic technique to remove the OTSC. Design: Prospective, single-arm, pilot study in an ex vivo porcine model.Interventions: Perforations were created by using a surgical scalpel and a blunt trocar. Then they were endoscopically closed with the OTSC. Next, the OTSC was removed under endoscopic control by inserting a 0.035-inch straight hydrophilic tip guidewire into the oval hole on the side of the OTSC jaw. Afterward, the OTSC clip was removed by pulling on the wire.Results: Fifteen perforations were closed: with the OTSC. In all of the cases, the endoscopic closure of the defects was feasible and effective. Successful visualization of the oval hole of the OTSC was possible in 12 cases (80%), and guidewire cannulation was possible in all of these 12 cases (100%). Advancement of the guidewire through the OTSC and then the lumen of the stomach was accomplished in 8 cases (53-3%). In all of the cases "with successful cannulation of the orifice, removal of the OTSC was managed safely. The result was an overall success rate of 53-3%> (8 of 15 cases).Limitations: Ex vivo porcine model.Conclusions: Guidewire removal is a new and feasible technique to remove the OTSC. Future studies should refine the technique to enhance visualization and cannulation of the oval hole of the OTSC.