首页> 外文期刊>Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function >Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population
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Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population

机译:血栓形成性遗传因素PAI-1 4G-4G和MTHFR 677TT是高加索人群酒精,隐源性肝硬化和门静脉血栓形成的危险因素

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The thrombophilic genetic factors (THRGFs), PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q and Prothrombin 20210A, were studied as risk factors in 865 Caucasian patients with liver cirrhosis, consecutively enrolled from June 2008 to January 2014. A total of 582 HCV, 80 HBV, 94 alcohol, (82 with more than one etiologic factor) and 191 cryptogenic patients with liver cirrhosis had been consecutively enrolled; 243 patients showed portal vein thrombosis (PVT). At least one of the above THRGFs was present in 339/865 patients (39.2%). PAI-1 4G-4G and MTHFR 677TT were the most frequent THRGFs, statistically significant in patients with alcohol, cryptogenic liver cirrhosis, and PVT: respectively 24 and 28, 50 and 73, and 65 and 83 (all chi-square tests >3.84, and p values <0.05). Two logistic regression analysis, using PAL-1 4G-4G and MTHFR 677TT, as dependent variable, confirmed the independent significant relationship of these THRGFs with alcohol, cryptogenic liver cirrhosis and PVT. PAI 1 and MTHFR 677 genotypes, deviated from those expected in populations in Hardy-Weinberg equilibrium (all p values <0.05), in the subgroups of patients with alcohol, cryptogenic liver cirrhosis and presence of PVT. Our study shows the pivotal role of PAI-1 4G-4G and MTHFR 67711' in patients with alcohol, cryptogenic liver cirrhosis, and PVT, in a Caucasian population. In conclusion, thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677TT, could have a role in the development of liver cirrhosis, mainly in patients without HCV and HBV, and PVT. (C) 2015 Elsevier B.V. All rights reserved.
机译:自2008年6月至2014年1月,共纳入865例白种人肝硬化患者的血栓形成遗传因子(THRGFs),PAI-1 4G-4G,MTHFR 677TT,V Leiden 506Q和凝血酶原20210A作为危险因素进行了研究。连续纳入582 HCV,80 HBV,94酒精(82个病因不只一种)和191例隐源性肝硬化患者。 243例患者出现门静脉血栓形成(PVT)。 339/865名患者中存在至少一种以上的THRGF(39.2%)。 PAI-1 4G-4G和MTHFR 677TT是最常见的THRGF,在酒精,隐源性肝硬化和PVT患者中有统计学意义:分别为24和28、50和73、65和83(所有卡方检验> 3.84 ,且p值<0.05)。使用PAL-1 4G-4G和MTHFR 677TT作为因变量的两次逻辑回归分析证实了这些THRGF与酒精,隐源性肝硬化和PVT的独立显着关系。酒精,隐源性肝硬化和PVT患者的亚组中,PAI 1和MTHFR 677基因型与Hardy-Weinberg平衡人群(所有p值均<0.05)中预期的基因型不同。我们的研究显示了PAI-1 4G-4G和MTHFR 67711'在高加索人群的酒精,隐源性肝硬化和PVT患者中的关键作用。总之,PAI-1 4G-4G和MTHFR 677TT的血栓形成和纤维形成机制可能在肝硬化的发展中起作用,主要是在无HCV和HBV以及PVT的患者中。 (C)2015 Elsevier B.V.保留所有权利。

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