Reply from Authors re: Prokar Dasgupta. Volume matters: Bladder injections of botulinum toxin type A. Eur Urol 2012;61:1185-6: Yes, Volume matters: Bladder injections of botulinum toxin type A

摘要

We greatly appreciated the timely and detailed editorial of Dr. Dasgupta regarding the present and putative future applications of onabotulinumtoxinA (OnabotA) to treat bladder pathologies [1]. Primarily focused on injection methods, he raises very exciting questions about the development of new methods to administer the neurotoxin. We particularly welcome the comments made on our recent study [2], but we think that some clarification is desirable. It is true that some clinical trials showed greater efficacy for higher volumes of injection [3], but we think that the lack of clear, objective outcome measurements and the low number of studies published justified a controlled experiment. We chose to use the presence of cleaved SNAP-25 protein as a marker of the action of OnabotA, allowing the correct identification of the affected bladder structures.