Editorial comment on: FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours.

摘要

I read with great interest the paper by van Oers et al in which the authors demonstrate that dysregulation of CK20 expression is an early event in the carcinogenesis of papillary noninvasive bladder cancer but occurs later than FGFR3 mutations. In particular, van Oers et al showed that the group of low-grade noninvasive papillary tumours is defined by the presence of FGFR3 mutation and normal CK20 expression. Personally, I had the pleasure of collaborating with some of the authors of this paper in a molecular study on FGFR3 mutations in urothelial papilloma .