Quality and application of oestrogen (ER) and progesterone receptor (PgR) and HER2 analyses

摘要

Oestrogen (ER) and progesterone receptor (PgR) status of breast carcinomas and HER2 over-expression are accepted prognostic/predictive parameters with undisputed clinical implications. Based on the recommendations of the 2005 St. Gallen Consensus [1], which have recently been re-emphasised during the 2007 Consensus, breast carcinomas may be clinically classified in three main categories according to their endocrine responsiveness. Highly endocrine responsive .tumours are characterised by extensive expression of both ER and PgR in more than 10% invasive tumour cells, lack of HER2 over-expression and low (less than 20%) Ki-67 labelling index (LI).