Synthesis, characterization and biological evaluation of some 16beta-azolyl-3beta-amino-5alpha-androstane derivatives as potential anticancer agents.

摘要

A series of new 16beta-azolyl-3beta-amino-5alpha-androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activity against the human cancer cell lines SW480, A549, HepG2, HeLa and SiHa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 muM against the five cancer cell lines.