Oral verrucous cai'cinoma (VC), also called oral florid papillomatosis, is a rare variant of squamous cell carcinoma, which can affect the oral mucosa, gingiva, tongue, floor of the mouth, and lips [1], It generally discloses an indolent behaviour, with a slow expanding growth, and minimal metastatic potential. Since transformation of VC into invasive squamous cell carcinoma may occasionally occur, there is a need for early and effective treatment modalities [1]. Various favouring factors have been implicated in oral VC, including the use of tobacco, alcohol, marijuana, chronic inflammatory diseases (e.g., oral ulcerative lichen planus), poor dental hygiene, immunosuppression, and human papillomavirus infection [ 1 ]. We present an aged patient with an extensive oral VC, effectively treated with a combination of topical imiquimod and CO2 laser.
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