Enhanced bioavailability of orally administered flurbiprofen by combined use of hydroxypropyl-cyclodextrin and poly(alkyl-cyanoacrylate) nanoparticles

摘要

Flurbiprofen was formulated into nanoparticle suspension to improve its oral bioavailability. Hydroxy-propyl-beta-cyclodextrin inclusion-flurbiprofen complex (HP-beta-CD-FP) was prepared, then incoiporating this complex into poly(alkyl-cyanoacrylate) (PACA) nanoparticles. HP-beta-CD-FP-PACA nanoparticle was prepared by the emulsion solvent polymerization method. The zeta potential was -26.8 mV, the mean volume particle diameter was 134 nm, drug encapsulation efficiency was 53.3 ± 3.6 % and concentration was 1.5 mg/mL. The bioavailability of flurbiprofen from optimized nanoparticles was assessed in male Wistar rats at a dose of 15 mg/kg. As compared to the flurbiprofen suspension, 211.6 % relative bioavailability was observed for flurbiprofen nanoparticles. The reduced particle size and increased surface area may contribute to improve oral bioavailability of flurbiprofen.