High resting heart rate predicts mortality, disability, and cognitive decline in patients after ischaemic stroke: Time for additional selective I (f) channel inhibitor trials?

摘要

Michael Bohm and co-workers1 have reported on the relationship of cardiovascular and neurological outcomes to baseline heart rate after ischaemic stroke in 20 165 patients (mean age 66.1, SD 8.6 years) with baseline heart rate data assigned to the treatment arms of the PRoFESS trial. Patients were grouped by quintiles of baseline heart rate and were evaluated for a primary outcome of recurrent stroke, a secondary outcome of the composite of recurrent stroke, myocardial infarction, or death from a vascular cause, and were further assessed for new or worsening heart failure and non-vascular death. Additional pre-defined endpoints were disability after recurrent stroke, assessed with the modified Rankin scale (mRS) and Barthel index at 3 months, and cognitive function, assessed with the Mini-Mental State Examination (MMSE) score at 4 weeks after randomization and at the penultimate visit.