Potential cytotoxic and selective effect of new benzobxanthenes against oral squamous cell carcinoma

摘要

The current work shows a new synthetic methodology to obtain 21 naphthoquinones that have been evaluated against oral cavity cancer. The compounds were obtained by a three-component reaction involving lawsone, dimedone and aromatic aldehydes catalyzed by lithium chloride undermicrowave irradiation to produce families of 1,4-and 1,2-naphthoquinones. Results: A clonogenic assay was performed on SCC9 cell line cultures with all compounds, revealing five very active compounds. In the 3,4,5-dimethylthiazol2,5-diphenyltetrazolium bromide cell viability assay using three different cell lines (SCC9, SCC4 and SCC25), 8c had an average IC50 of approximately 1.45 mu M capable of reducing tumor cell viability, approximately 90-times higher than carboplatin. Conclusion: Therefore, the xanthene-naphthoquinone derivatives show promising bioactivity for oral cavity cancer treatment.