Acute phase proteins as biological markers of addictive disorders in teenagers and children.

摘要

Acute phase proteins (APP), including C-reactive protein (CRP), alpha-1-proteinase inhibitor (PI) activity and albumin level were studied in serum of 183 teenagers and children with drug addictive disorders (DAD) (mainly home-made opiate dependence and glue-sniffing), hospitalised at Municipal Drug Addictive Centre, Novosibirsk (1996-1999). Serum CRP concentration increased several times during early withdrawal period in the teenager group with opiate dependence. In most cases of DAD decreased level of albumin (negative APP reactant) as well as decreased activity of PI was revealed. After treatment (about 21 days after onset of hospitalisation) the level of albumin still remained decreased. These indexes were suggested as a possible surrogate biological marker of DAD, and immune-stimulators were recommended during DAD treatment to restore the decreased level of protective APP of these patients.