Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

Storozheva ZI; Proshin AT; Zhokhov SS; Sherstnev VV; Rodionov IL; Lipkin VM; Kostanyan IA

首页> 外文期刊>Bulletin of experimental biology and medicine >Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

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Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

机译：六肽HLDF-6和PEDF-6在用β-淀粉样肽Abeta（25-35）进行慢性脑室内治疗后可恢复大鼠的记忆力。

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Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. Peptides HLDF-6 and PEDF-6 possessed neuroprotective activity and counteracted the toxic effect of Abeta(25-35). Peptides HLDF-6 and PEDF-6 mainly improved long-term memory and working memory, respectively.

机译：在动物社会识别测试和莫里斯水迷宫中研究了同源肽HLDF-6和PEDF-6对慢性脑室内给予β-淀粉样肽Abeta（25-35）诱导的实验性阿尔茨海默氏病动物行为的影响。肽HLDF-6和PEDF-6具有神经保护活性，并抵消了Abeta（25-35）的毒性作用。肽HLDF-6和PEDF-6分别分别改善了长期记忆和工作记忆。

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来源
《Bulletin of experimental biology and medicine》 |2006年第3期|共4页
作者
Storozheva ZI; Proshin AT; Zhokhov SS; Sherstnev VV; Rodionov IL; Lipkin VM; Kostanyan IA;
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正文语种 eng
中图分类基础医学;
关键词
Amyloid beta-Protein; Eye Proteins; Memory; Nerve Growth Factors; Oligopeptides; 淀粉样β蛋白; 眼蛋白质类; 记忆; 神经生长因子; 寡肽类; 肽碎片; 舍平类;

机译：Amyloid beta-Protein;Eye Proteins;Memory;Nerve Growth Factors;Oligopeptides;淀粉样β蛋白;眼蛋白质类;记忆;神经生长因子;寡肽类;肽碎片;舍平类;

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1. Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35). [J] . Storozheva ZI, Proshin AT, Zhokhov SS, Bulletin of experimental biology and medicine . 2006,第3期

机译：六肽HLDF-6和PEDF-6在用β-淀粉样肽Abeta（25-35）进行慢性脑室内治疗后可恢复大鼠的记忆力。
2. Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Abeta peptide (Abeta(25-35)). [J] . El-Agnaf OMA, Irvine GB, Fitzpatrick G, The Biochemical Journal . 1998,第Pta2期

机译：对代表阿尔茨海默病Abeta肽（Abeta（25-35））所谓的速激肽样区域的肽的比较研究。
3. Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease. [J] . Srivareerat M, Tran TT, Salim S, Neurobiology of Aging: Experimental and Clinical Research . 2011,第5期

机译：慢性尼古丁可恢复阿尔茨海默氏病Abeta大鼠模型的正常Abeta水平，并防止短期记忆和E-LTP损伤。
4. Aggregation studies of beta-amyloid 25-35 fragment in interaction with other modified beta-amyloid peptide fragments [C] . Lukasz P.Frankiewicz, Wiktor Banachewicz, Aleksandra Misicka International Peptide Symposium;European Peptide Symposium . 2005

机译：与其他改性β-淀粉样蛋白肽片段相互作用β-淀粉样蛋白25-35片段的聚集研究
5. Effects of estrogen treatment on working memory impairments induced by beta-amyloid and ibotenic acid in female rats [D] . Hruska, Zuzana 2003

机译：雌激素治疗对雌性大鼠β淀粉样蛋白和异丁烯酸诱导的工作记忆障碍的影响
6. Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Abeta peptide Abeta(25-35). [O] . O M El-Agnaf, G B Irvine, G Fitzpatrick, 1998

机译：对代表阿尔茨海默病Abeta肽Abeta（25-35）所谓的速激肽样区域的肽的比较研究。
7. Chronic but not acute intracerebroventricular administration of amyloid ß-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus [O] . Burgos Ramos Emma, Hervás Aguilar América, Puebla Jiménez Lilian, 2007

机译：慢性而非急性脑室内给予淀粉样蛋白ß-肽（25-35）可降低大鼠海马中的生长抑素含量，腺苷酸环化酶活性，生长抑素诱导的腺苷酸环化酶活性抑制和腺苷酸环化酶I水平

Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

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