The Use of Nanosized Cortisol-Polymer Complex for Analysis of Mechanisms of Regulation of Functional Activity of Skin Fibroblast

摘要

Cortisol in concentrations within the therapeutic range inhibits calcium response of fibroblast to angiotensin II. In physiological concentrations, cortisol potentiates the effects of angio-tensin II via modulation of membrane mineralocorticoid receptors. The inhibitory effects of glucocorticoids on cell proliferation and collagen synthesis are manifestations of its genomic effects mediated by intracellular receptors. The use of glucocorticoid preparation based on nanosized polymer structure made it possible to distinguish between the genomic and nonge-nomic mechanisms of regulation of activity of target-cells.