A randomized, open-label, comparative study of oral doxycycline 100 mg vs. 5% topical benzoyl peroxide in the treatment of mild to moderate acne vulgaris.

摘要

Acne is one of the most common dermatologic conditions seen in medical practice, affecting almost 80-85% of young adults. The pathogenesis of acne is multifactorial, involving seborrhea, microbial proliferation (Propionibacterium acnes), inflammation, and abnormal follicular desquamation.Benzoyl peroxide has been used since the 1930s and has antibacterial, keratolytic, and comedolytic properties; it is also highly lipophilic.It comes in varying strengths of 2.5%-10%.