Intraocular pressure (IOP) is a major risk factor for glaucoma and reduction of IOP is currently the only treatment for glaucoma. Study of the physiologic parameters that contribute to IOP is the basis of aqueous humor dynamics. For most glaucoma patients, reduction of IOP begins with eye drops using 1 or more classes of medications. Understanding the mechanisms of action of these medications provides insight into the efficacy and persistency of IOP lowering,1"3 and can play an important role in selection of therapy in glaucoma management. This paper will review the assessment of aqueous humor dynamics in humans, its application to the determination of mechanisms of action, and implications for the selection of glaucoma therapy.
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