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Epigenetics and Future Generations

机译:表观遗传学和后代

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Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic programming despite the non-identity argument, which challenges this rationale in case of policies that affect the number and identity of future people. We propose that rights based obligations grounded in the interests of non-existing people might fall upon existing people when generations overlap. In particular, if environmental exposure in F0 (i.e. existing people) will affect the health of F2 (i.e. non-existing people) through epigenetic programming, then F1 (i.e. existing and overlapping with both F0 and F2) might face increased costs to address F2's condition in the future: this might generate obligations upon F0 from various distributive principles, such as the principle of equal opportunity for well being.
机译:关于疾病风险的代际表观遗传程序设计的最新证据将公共卫生预防干预措施的范围扩大到了子孙后代,即不存在的人们。由于表观遗传易感性的传播,吸烟或不健康饮食等生活方式可能会影响几代人的健康。尽管可以通过非个人化的考虑(例如使整体福祉最大化)来为子孙后代的健康制定合理的政策,但在本文中,我们探讨了尽管存在非同一性的论点,但代际表观遗传计划中是否存在基于权利的义务取代了这一挑战,如果政策影响到未来人的数量和身份,则应遵循此基本原则。我们建议,当世代重叠时,基于不存在人民利益的基于权利的义务可能落在现有人民身上。特别是,如果F0(即现有人员)的环境暴露将通过表观遗传程序编程影响F2(即不存在的人员)的健康,则F1(即现有人员并与F0和F2重叠)可能会面临解决F2的成本增加的问题。未来的状况:这可能会根据各种分配原则(例如,平等机会的幸福原则)对F0产生义务。

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