ENGINEERING PHOTOSYNTHESIS - SYNTHETIC REDOX PROTEINS

摘要

The understanding of the principal parameters naturally selected to engineer biological electron transfer systems has been combined with techniques of de novo design and chemical synthesis of peptides to initiate a program of synthesis of simple proteins equipped with multiple redox cofactors. Our primary goal is to assemble functional redox protein maquettes of the large, complicated natural proteins such as the photosynthetic reaction center. Attention is focused on strategies for engineering and construction of well defined, stable four-helix bundles containing suitable redox cofactors optimized for efficient electron transfer. [References: 12]