SYNTHESIS AND PROTONATION BEHAVIOUR OF THE MACROCYCLE 2,6,10,13,17,21-HEXAAZA[22]METACYCLOPHANE - THERMODYNAMIC AND NMR STUDIES ON THE INTERACTION OF 2,6,10,13,17,21-HEXAAZA[22]METACYCLOPHANE AND ON THE OPEN-CHAIN POLYAMINE 4,8,11,15-TETRAAZAOCTADECA

摘要

The novel cyclophane receptor 2,6,10,13,17,21-hexaaza[22]metacyclophane (L) has been synthesised and characterised. The acid-base behaviour and interaction with ATP, ADP and AMP have been studied by potentiometry in 0.15 mol dm(-3) at 298.1 K and multi nuclear NMR. L presents in its protonated forms a molecular organization which enables its multipoint binding with nucleotides. Salt-bridge formation occur between the polyammonium sites of L and the phosphate chain of the nucleotides while pi-stacking between the meta-phenylene subunit incorporated in the receptor and the adenine ring of the nucleotides. [References: 32]