Avoiding stent thrombosis: advances in technique, antiplatelet pharmacotherapy and stent design

摘要

Definitions for stent thrombosisHistorically, stent thrombosis (ST) was proven angiographically by the demonstration of thrombus at the site of a previously placed stent with impaired downstream flow, or inferred clinically in patients with subsequent myocardial infarction (MI), target-lesion revascularization (TLR) or unexplained sudden death. While the angio-graphic definition of ST may underestimate the true incidence by not including patients who fail to survive to angiography, the clinical definition may overestimate the incidence by including events not attributable to ST. Definitions of ST, therefore, require a compromise between sensitivity and specificity. Clinical trials evaluating first-generation bare-metal stents (BMS) defined ST differently, leading to disparities in the reported incidence and making comparisons between studies problematic.