Low avidity and level of serum anti-abeta antibodies in patients with cerebral amyloid angiopathy-related cerebral hemorrhage.

摘要

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the beta-amyloid protein (Abeta) in small cerebral vessels, which is considered a common cause of intracerebral hemorrhage (CAAH) in elderly people. Little is known about the properties of serum naturally occurring anti-Abeta antibodies in patients with CAAH. We investigated the avidity and levels of anti-Abeta antibodies in 20 patients and 20 age-matched healthy controls by an enzyme-linked immunosorbent assay with thiocyanate elution. Our study revealed that both the levels and the avidity of these endogenous anti-Abeta antibodies were lower in patients with CAAH than in controls, which may be a new mechanism for the impaired clearance of cerebral Abeta and have important implications for the development of immune-based therapeutic strategies for CAA.