Why genomics shouldn't get too personal: In favor of filters: Re: Invited Comment by Holly K. Tabor et al. in American Journal of Medical Genetics Part A Volume 155.

摘要

We read with great interest the recent Invited Comment by Tabor et al. on the new ethical challenges raised by exome sequencing and whole genome sequencing (ES/WGS) [Tabor et al., 2011]. We are in general agreement with their position that ES/WGS fundamentally challenge assumptions valid for other genetic sequencing techniques in the areas of informed consent, data sharing, and unanticipated findings. What we would like to add is the query whether it is in fact desirable to generate so many unanticipated findings.