Spontaneous coronary artery dissection in a young woman with Loeys-Dietz syndrome

摘要

Spontaneous coronary artery dissection is a rare condition often presenting as acute coronary syndrome or sudden death, with an estimated prevalence of 0.1-1.1% in angiographic series and with preponderance of younger females. Even though the most frequent cause is atherosclerotic plaque rupture, in young patients spontaneous and isolated coronary artery dissection are reported in peripartum women, Ehlers-Danlos syndrome, during intense physical exercise and in cocaine abuse [Vrints, 2010]. The present case report highlights the importance to consider the possibility of a connective-tissue disorder as potential cause of spontaneous coronary artery dissection. A 35-year-old woman, who was seen in the emergency room for recent intermittent chest discomfort, was transferred to the Cardiology Department with acute chest pain and electrocardiographic signs of myocardial infarction. The patient did not present any atherosclerotic risk factor, except moderate smoke habit (three cigarettes daily).