Friedel-Crafts Polyketones:Synthesis, Thermal and Antimicrobial Properties

摘要

Linear polyketones A-D and copolyketones E, F containing N-methylpiperidinone in the main chain were synthesized via Friedel-Crafts reaction through the polymerization of 2,6-bisfurfurylidene N-methyl piperidone (2,6-BFNP) with different diacid chlorides. The model compound was synthesized by reacting (2,6-BFNP) with benzoyl chloride and characterized by 1H-NMR, FTIR and elemental analyses. The resulting polyketones and copolyketones were identified by elemental and spectral analyses, and characterized by solubility, viscometry, X-ray and morphology measurements. The thermal properties of these polyketones and copolyketones were evaluated and correlated to their structural units by TGA and DTA measurements. All the polyketones were tested for their biological activity against bacteria, fungi and yeast. It was observed that the majority of the polyketones and the copolymers synthesized can be used as antibacterial and antifungal agents.