Molecular analysis of complex cases of alpha- and beta-thalassemia in Mexican mestizo patients with microcytosis and hypochromia reveals two novel alpha(0)-thalassemia deletions --(Mex1) and --(Mex2)

摘要

IntroductionAlpha-thalassemia (-thal) is a common monogenic disorder worldwide. In mixed ethnic populations, -thal and beta-thalassemia (-thal) can be expected, sometimes giving complex phenotypes, which without molecular analysis are not easily explained. We performed the molecular identification of - and -thal alleles in 51 Mexican patients with microcytosis, hypochromia, and normal or low levels of HbA(2).