首页> 外文期刊>International Journal of Cardiology >Decreased serum endogenous secretory receptor for advanced glycation endproducts and increased cleaved receptor for advanced glycation endproducts levels in patients with atrial fibrillation
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Decreased serum endogenous secretory receptor for advanced glycation endproducts and increased cleaved receptor for advanced glycation endproducts levels in patients with atrial fibrillation

机译:房颤患者晚期糖基化终产物的血清内源性分泌受体减少,而晚期糖基化终产物的裂解受体增加

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摘要

This clinical protocol was approved by the institutional Medical Ethics Committee and conducted according to the ethical guidelines outlined in the Declaration of Helsinki. A total of 72 consecutive atrial fibrillation (AF) patients who understood this experiment and agreed to participate in this study were enrolled. Another 30 age- and sex-matched healthy people who understood this experiment and agreed to participate in this study were considered as control group. Detailed medical history, physical examination, routine biochemical testing, and 12-lead electrocardiograms were performed both in AF patients and control group. Valvular functions, left ventricular size (left ventricular end-diastolic dimension, LVEDD) and functions (left ventricular ejection fraction, LVEF), and left atrial diameter (LAD) were evaluated by echocardiography. The diameter of the left atrium was measured in parasternal long axis view. AF duration was determined by the patient's description of a well-defined and abrupt onset palpitation with subsequent electrocardiogram evidence of AF at the time of presentation. Exclusion criteria were as follows: structural heart disease, coronary artery disease, left ventricular ejection fraction less than 45%, other types arrhythmias, surgery or stroke within 6 months, a history of infection, chronic inflammatory, hepatic or malign disease, chronic renal failure, autoimmune diseases, abnormal thyroid function, imbalance of electrolytes, use of anti-inflammatory drugs such as corticoids, and nonsteroidal anti-inflammatory drugs excluding aspirin.
机译:该临床方案已由机构医学伦理委员会批准,并根据《赫尔辛基宣言》中概述的伦理准则进行。总共入选了72名连续的房颤(AF)患者,他们理解该实验并同意参加该研究。理解该实验并同意参加本研究的另外30个年龄和性别匹配的健康人被视为对照组。在AF患者和对照组中均进行了详细的病史,体格检查,常规生化检查和12导联心电图检查。通过超声心动图评估了瓣膜功能,左心室大小(左心室舒张末期尺寸,LVEDD)和功能(左心室射血分数,LVEF)和左心房直径(LAD)。在胸骨旁长轴视图中测量左心房的直径。心房颤动的持续时间取决于患者对明确而突然发作的心电图的描述,并在出诊时伴有心电图证据。排除标准如下:结构性心脏病,冠状动脉疾病,左心室射血分数小于45%,其他类型的心律不齐,6个月内手术或中风,感染史,慢性炎症,肝或恶性疾病,慢性肾功能衰竭,自身免疫性疾病,甲状腺功能异常,电解质失衡,使用抗炎药(如皮质类固醇)和非甾体抗炎药(阿司匹林除外)。

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