We appreciate the concerns raised by Sand-berg et al in their recent letter pertaining to the design and statistical methods of our analysis described in our recent article, and we welcome the opportunity to respond to each point raised.We agree that ideally the best 'gold standard' study design would involve the use of matched controls, matching on eye function at baseline, as we plan to do in our upcoming clinical trial. For preliminary pilot studies, however, other study designs, including methodologies that do not have controls, can aiso be meaningful, especially when the objectives are to assess treatment potential and establish the equipoise necessary for further investigation in a randomised control study.
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