Impact of high-dose statin pre-treatment and contrast-induced acute kidney injury on follow-up events in patients with acute coronary syndrome undergoing percutaneous coronary intervention

摘要

Contrast-induced acute kidney injury (CI-AKI) is associated with increased morbidity and mortality [1]. Randomized investigations showed that short-term pre-treatment with high-dose statins prior to coronary angiography or intervention reduces the incidence of CI-AKI, especially in the setting of acute coronary syndrome (ACS) [2,3]; pleiotropic effects may explain this benefit. To date, it is unknown whether renal protection provided by statins in such patients translates also into improvement of clinical outcome during long-term follow-up; in order to test such hypothesis, we have pooled individual follow-up data from the patients' population of two published randomized studies that have demonstrated a significant CI-AKI reduction by pre-treatment with high-dose statin (vs no statin pre-treatment) in statin-naive patients undergoing early percutaneous coronary intervention (PCI) for non ST-segment elevation ACS [2,31.