Second-trimester pregnancy termination with oral misoprostol in women who have had one cesarean section.

摘要

Misoprostol, a prostaglandin (PG) E-, analog, has become an important drug in the practice of obstetrics and gynecology not only for its ability to bring about cervical changes and uterine contractions but also for its low cost, easy storage at room temperature, and minimal adverse effects. Spontaneous labor in women with a prior uterine scar rarely leads to problems, but there is a risk of uterine rupture and dehiscence with induced labor , Although there are several reports in the literature about misoprostol administration inwomen with scarred uterus at term, only few address its use in the second trimester .Between January 1998 and January 2004, 57 pregnant women consecutively underwent second-trimester pregnancy termination with oral misoprostol in the Obstetrics and Gynecology Department of Baskent University Hospital. Indications for termination included intrauterine fetal death, fetal structural abnormalities, and chromosomal abnormalities. The women in the study were assigned to 1 of 3 groupsaccording to the previous delivery routes: group 1 (n=29) consisted of women who had previous vaginal delivery, group 2 (n = 16) of nulliparous women, and group 3 (n = 12) of women with a history of 1 low segment transverse cesarean delivery. The regimen used in all women was 200 mug of misoprostol orally every hour for a maximum of 6 tablets (1200 mug) per day.