Efficiency of Liposomal Drug Delivery System Against Plasmodium In Vitro and In Vivo Culture

摘要

Liposomes are the leading drug delivery systems for the systemic (intravenous) administration of drugs. Liposome encapsulation can markedly alter the biodistribution and pharmacokinetics of well-known chemotherapeutic agents. Present work explore liposomal drug delivery system for anti-malarial drugs with the objective of protection of the drug from the degradation and the sustained release of the drug along with minimization of their adverse effects. Azadirachta indica, Cinchona officinalis and Artemisia annua having anti Plasmodium activities and chloroquine, mefloquine, artesunate synthetic drugs were selected in the study. In vitro Plasmodium culture was maintained by modified method Trager and Jenson (1997). In vivo Culture were maintained andscreened as method performed by Peter et. al,(1975) . Effect of antimalarial (natural and synthetic) molecule entrapped in liposome and in free form were measured. Results indicated that synthetic as well as plant extracts exhibits better response when given in liposomal form, both in vivo and in vitro conditions. Which is in accordance to ability of liposomes to entrap hydrophilic and hydrophobic drugs with concomitant reduction in their toxicity potential, their versatility and their amenability for surface modification are the major factors responsible for their popularity in drug delivery research.