Effects of glucosinolate breakdown products on the hepatic biotransformation system in male rats

摘要

AbstractThe effects of 5‐vinyloxazolidine‐2‐thione (VOT), 1‐cyano‐3‐butene (CYB) and various isothiocyanates on parameters of hepatic phase I and phase II biotransformation were investigated in male rats after oral treatment for 3 consecutive days. The compounds with the exception of CYB caused increases in liver weight and glutathion S‐transferase activity. Cytochrome P‐450 level and monooxygenase activities were decreased by the isothiocyanates and CYB. Administration of VOT resulted in contrasting response of monooxygenases: reduced aminopyrine N‐demethylation and enhanced aniline hydroxylation. Possible mechanis