Re: Hypergonadotropic hypogonadism in a patient with inv ins (2;4).

摘要

We have read with great interest the article by Tzschach et al. (2007) about a 30-year-old man with azoospermia, primary hypogonadism and minor dysmorphic features who carried a balanced insertional chromosome translo-cation inv ins (2p24;4q28.3q31.22) de novo. In their contribution, the authors concluded that this chromosome aberration suggests the localization of a gene for a primary hypogonadism in either 2p24 or 4q28-31