Polymorphic tandem repeat region in interleukin-1α intron 6

摘要

Analysis of polymerase chain reaction amplified products from the sixth intron of the human interleukin-1α gene reveals a high polymorphism (polymorphism information content = 0.51) in a Caucasian population. Altogether, seven alleles have been defined ranging from 620 to 1220bp. This polymorphism is probably attributable to a variable number of 46-bp tandem repeats, each containing potential regulatory sequences