Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.

摘要

BACKGROUND: A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis. OBJECTIVE: The objective was to assess whether established genetic variants, mainly from genomewide association studies, modify dietary patterns in predicting diabetes risk. DESIGN: We determined 10 polymorphisms in a prospective, nested, case-control study of 1196 diabetic and 1337 nondiabetic men. A genetic risk score (GRS) was generated by using an allele counting method. Baseline dietary intakes were collected by using a semiquantitative food-frequency questionnaire. We used factor analysis to derive Western and "Prudent