Senile cardiac amyloidosis.

摘要

Senile cardiac amyloidosis (SCA) is an underdiagnosed condition resulting from massive cardiac deposition of wild-type transthyretin (TTR). The heart is typically affected in isolation unlike other forms of amyloid: 50% of patients with AL amyloid have clinical cardiac involvement, but only 5% have cardiac involvement in isolation while AA amyloidosis almost never produces clinically apparent heart disease. An enhanced appreciation of the clinical presentation of SCA might facilitate recognition and diagnosis.