ASSOCIATIONS BETWEEN DIETARY INFLAMMATORY INDEX SCORES AND INFLAMMATORY BIOMARKERS AMONG OLDER ADULTS IN THE LOTHIAN BIRTH COHORT 1936 STUDY

摘要

Objectives: Chronic low-grade inflammation is a key underlying mechanism in several age-related chronic conditions and previous studies have shown that diet can modulate the inflammatory process. We investigated the ability of the Dietary Inflammatory Index (DII (R)), a summary measure of dietary inflammatory potential, to predict concentrations of plasma inflammatory markers in a sample of older people. Design: Cross-sectional and 3-year follow-up analysis of Lothian Birth Cohort 1936 (LBC1936) study data. Setting: Baseline data collection occurred between 2004 and 2007 in Edinburgh, Scotland. Participants: Men and women (n 928, age similar to 70 at baseline) living in Edinburgh and surrounding regions who are surviving participants of the Scottish Mental Survey of 1947. Measurements: Energy-adjusted DII (E-DII) scores at age 70 (derived from a food-frequency questionnaire), plasma concentrations of inflammatory biomarkers at age 70 (C-reactive protein (CRP), fibrinogen) and age 73 (CRP, fibrinogen, hs-CRP, Interleukin-6 (IL-6)). Analyses were performed using multivariable logistic regression adjusting for age, sex, smoking, body mass index, physical activity, and hypercholesterolaemia. Results: Higher E-DII scores (pro-inflammatory diet) were associated with increased odds of elevated CRP (>3mg/L) at age 70 (OR 1.12; 95 CI: 1.02, 1.24, P = 0.02), and elevated IL-6 (>1.6pg/ml) at age 73 (OR 1.11; 95 CI: 1.00, 1.23, P = 0.04), but not with fibrinogen. Conclusion: These results are consistent with the ability of the DII to predict inflammatory biomarker concentrations and suggest that diet plays a role in the regulation of inflammation, even after controlling for potential confounders. This validation study provides support for using the DII in research among older populations.