Population data on acute infantile and chronic childhood spinal muscular atrophy in Warsaw

摘要

This study provides epidemiological data on acute infantile (ASMA) and chronic childhood spinal (CSMA) muscular atrophy in Warsaw for the period 1976–1985. All calculations are based on the assumption that ASMA and CSMA result from mutations at two different gene loci. The incidence of ASMA and CSMA was 1 in 19474 live births with a corresponding gene and carrier frequency of 714 × 10−5 and 1 in 70, respectively. The prevalance of CSMA for the year 1985 was 1.26 × 10−5. These figures are higher than in similar studies in other countries. This fact might be connected with the careful ascertainment in thi