A search for the indianapolis-variant of human alcohol dehydrogenase in liver autopsy samples from North Germany and Japan

摘要

Human liver alcohol dehydrogenase (ADH) variants were screened in random autopsy specimens from 53 North German and 34 Japanese individuals. Based on pH-activity profile and electrophoretic pattern, only ADH2and ADH3variants were detected. In relatively fresh specimens, an “anodic band” or “π-ADH” band was also observed. The recently reported new molecular forms collectively called “ADHIndianapolis” (Bosron et al. 1980) could not be demonstrated and therefore may be confined hitherto only to the American blac