Linkage relationships of X-linked choroideremia to DXYS1 and DXS3

摘要

Choroideremia is a distinct blinding condtion with an X-linked pattern of inheritance. We have analyzed two RFLPs, DXS3 and DXYS1, for linkage with the choroideremia locus (TCD) within three kindreds. A maximum LOD score of 3.98 was obtained at$$hat theta = 0.14$$. Contrary to previous reports, the present data demonstrate that these two RFLPs are not tightly linked to the choroideremia gene locus.