A randomized clinical trial in vitamin D-deficient adults comparing replenishment with oral vitamin D-3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood

摘要

Background: Vitamin D deficiency, defined as a serum 25-hydroxy-vitamin D 25(OH) D concentration,20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol concentrations or raise HDL-cholesterol concentrations. This uncoupling between association and causation may result from a failure of oral vitamin D to mimic the effect of dermally synthesized vitamin D in response to ultraviolet type B (UVB) light.