Syntheses, crystal structures and anticancer activities of three novel transition metal complexes with Schiff base derived from 2-acetylpyridine and 1-tryptophan

摘要

Three novel transition metal coordination complexes, Cu(C_(18)H_(16)N3O2)2·2CH3OH (1), Zn(C_(18)H_(16)N3O2)2·2-CH3CH2OH (2) and Cd(C_(18)H_(16)N3O2)2·2CH3OH (3) (C_(18)H_(16)N3O2: 2-acetylpyridine-L-tryptophan) have been synthesized and characterized by IR, UV, elemental analysis,~1H NMR and X-ray diffraction single crystal analysis. The three crystals crystallize in the tetragonal crystal system, space group P432_12. They are all six-coordinated by two nitrogen atoms from C=N, two nitrogen atoms from pyridine rings and two carboxylic oxygen atoms in different ligands, forming a distorted octahedron geometry. Each ligand serves as a bridging ligand to link metal ions through carboxylic oxygen atoms, leading to a three-dimensional coordination polymer. The anticancer activities of these three complexes on MDA-MB-231 breast cancer cells were also investigated. The results indicate that all of the three complexes can inhibit the cellular proliferation. Furthermore, Cd(C_(18)H_(16)N3O2)2·2CH3OH (3) has the highest anti-proliferative activity among the three complexes. In addition, Cd(C_(18)H_(16)N3O2)2 · 2CH3OH (3) can inhibit proteasomal chymotrypsin-like activity and also can induce apoptosis on human breast cancer MDA-MB-231 cells.