An efficient entry to furo[2,3-d]pyrimidines via inverse electron demand Diels-Alder reactions of 2-aminofurans with 1,3,5-triazines

摘要

Furo[2,3-d]pyrimidines were readily prepared via an inverse electron demand Diels-Alder (IDA) reaction between 2-aminofurans and 1,3,5-triazines. 2-Aminofurans proved to be productive dienophiles leading to the IDA product in moderate to good yields. This study further expanded the scope of 1,3,5-triazine IDA reactions with five-membered aromatic heterocycles as dienophiles.