Hypercalcaemia in diffuse large B-cell lymphoma with expression of both parathyroid hormone-related protein and its receptor.

摘要

A 58-year-old man was admitted to our hospital because of an enlarged right inguinal lymph node. Histological examination of the right inguinal lymph node biopsy revealed a diffuse proliferation of large lymphoid cells (top left). Clinical findings were consistent with diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), stage IIIA. Following treatment with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) and R-ESHAP (rituximab, etoposide, methylprednisolone, cytarabine, and platinum), the disease relapsed again. The patient became refractory to chemotherapy and did not achieve remission again. He was administered palliative therapy with irinotecan hydrochloride at a dose of 40 mg/m2 for 3 d. Two months later, the patient developed progressive lumbodorsal pain and nausea. Enlarged lymph nodes were palpable in the right cervical, supraclavicular and inguinal regions.